MersV1, Main, Exploration, bibRecord, 003540

Majority of peptides binding HLA-A∗0201 with high affinity crossreact with other A2-supertype molecules

Identifieur interne : 003540 ( Main/Exploration ); précédent : 003539; suivant : 003541

Majority of peptides binding HLA-A∗0201 with high affinity crossreact with other A2-supertype molecules

Auteurs : John Sidney [États-Unis] ; Scott Southwood [États-Unis] ; Dean L. Mann [États-Unis] ; Marcelo A. Fernandez-Vina [États-Unis] ; Mark J. Newman [États-Unis] ; Alessandro Sette [États-Unis]

Source :

Human Immunology [ 0198-8859 ] ; 2001.

RBID : ISTEX:D13E8F851E4F930C8E4546AE332F6D49A7C21DA9

English descriptors

Abstract

Abstract: The A∗0201, A ∗0202, A∗0203, A∗0206, and A∗6802 binding capacity of single amino acid substitution analogs of known A2-supertype binding peptides and of large nonredundant peptide libraries was measured. The results were utilized to rigorously define the peptide binding specificities of these A2-supertype molecules. Although each molecule was noted to have unique preferences, large overlaps in specificity were found. The presence of L, I, V, M, A, T, and Q residues in position 2, and L, I, V, M, A, and T residues at the C-terminus of peptide ligands were tolerated by all molecules. Likewise, whereas examination of secondary influences on peptide binding revealed allele specific preferences, shared features could also be identified. These shared features were utilized to define an A2-supermotif and were noted to correlate with crossreactivity. Over 70% of the peptides that bound A ∗0201 with high affinity were found to bind at least two other A2-supertype molecules. Because the A2-supertype molecules studied herein cover the variants most common in different major ethnicities, these findings have important implications for epitope-based approaches to vaccination, immunotherapy, and the monitoring of immune responses.

Url:

https://api.istex.fr/ark:/67375/6H6-DPWMG9FG-C/fulltext.pdf

DOI: 10.1016/S0198-8859(01)00319-6

Affiliations:

États-Unis

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Le document en format XML

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<author><name sortKey="Mann, Dean L" sort="Mann, Dean L" uniqKey="Mann D" first="Dean L." last="Mann">Dean L. Mann</name>
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<author><name sortKey="Fernandez Vina, Marcelo A" sort="Fernandez Vina, Marcelo A" uniqKey="Fernandez Vina M" first="Marcelo A." last="Fernandez-Vina">Marcelo A. Fernandez-Vina</name>
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<term>antigens</term>
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<term>immunochemistry</term>
<term>peptides</term>
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<term>Anchor</term>
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<term>More molecules</term>
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<term>Optimal residue</term>
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<term>Pathogen origin</term>
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<term>Peptides binding</term>
<term>Position residue</term>
<term>Positive effects</term>
<term>Predictive algorithms</term>
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<front><div type="abstract" xml:lang="en">Abstract: The A∗0201, A ∗0202, A∗0203, A∗0206, and A∗6802 binding capacity of single amino acid substitution analogs of known A2-supertype binding peptides and of large nonredundant peptide libraries was measured. The results were utilized to rigorously define the peptide binding specificities of these A2-supertype molecules. Although each molecule was noted to have unique preferences, large overlaps in specificity were found. The presence of L, I, V, M, A, T, and Q residues in position 2, and L, I, V, M, A, and T residues at the C-terminus of peptide ligands were tolerated by all molecules. Likewise, whereas examination of secondary influences on peptide binding revealed allele specific preferences, shared features could also be identified. These shared features were utilized to define an A2-supermotif and were noted to correlate with crossreactivity. Over 70% of the peptides that bound A ∗0201 with high affinity were found to bind at least two other A2-supertype molecules. Because the A2-supertype molecules studied herein cover the variants most common in different major ethnicities, these findings have important implications for epitope-based approaches to vaccination, immunotherapy, and the monitoring of immune responses.</div>
</front>
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<name sortKey="Fernandez Vina, Marcelo A" sort="Fernandez Vina, Marcelo A" uniqKey="Fernandez Vina M" first="Marcelo A." last="Fernandez-Vina">Marcelo A. Fernandez-Vina</name>
<name sortKey="Mann, Dean L" sort="Mann, Dean L" uniqKey="Mann D" first="Dean L." last="Mann">Dean L. Mann</name>
<name sortKey="Newman, Mark J" sort="Newman, Mark J" uniqKey="Newman M" first="Mark J." last="Newman">Mark J. Newman</name>
<name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name>
<name sortKey="Southwood, Scott" sort="Southwood, Scott" uniqKey="Southwood S" first="Scott" last="Southwood">Scott Southwood</name>
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Majority of peptides binding HLA-A∗0201 with high affinity crossreact with other A2-supertype molecules

Majority of peptides binding HLA-A∗0201 with high affinity crossreact with other A2-supertype molecules

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri